ERBB2 and breast cancer: In one single-arm open-label study sponsored by the NSABP Foundation (NSABP FB-12/FACT-1), early stage HER2-negative breast patients identified by the CELx HSF test to have abnormal HER2 signaling will receive the same standard of care therapy regimen early stage HER2+ breast cancer patients (chemotherapy plus trastuzumab plus pertuzumab) receive.