The rationale for conducting these trials in an early stage neoadjuvant setting is based on the fact that early stage HER2+ breast cancer patients treated with neoadjuvant anti-HER2 therapies have been found to have significantly higher rates of pathological complete response than early stage HER2-negative patients receiving standard of care neoadjuvant chemotherapies (Cortazar et al. 2014). Here, ERBB2 is linked to breast carcinoma.