VMA21 and cancer: Existing reports indicate that circHIPK3, which originated from exon 2 of the HIPK3 gene and localized in the cytoplasm, was involved in the regulation of proliferation and migration of various cancer cells via sponging miRNAs.16, 17, 18, 19 circVMA21 was derived from the third exon of VMA21 gene, located in the cytoplasm, and acted as a sponge of miR-200c to alleviate cell apoptosis.33