TP53 and neoplasm: Transformation of the tubal epithelium seems to follw the clonal evolution model with step-wise accumulation of muttions and loss of progesterone clearance on the p53 initiated secretory known as  "p53 signature" and evenetually ends with serous tubal intraepithelial carcinoma and HGSC [7]. Although the secretory cell linage is regarded to be the origin of HGSOC, the stemness characteristic of the so called tumor initiation cell in the fallopian tube epithelium has not been well elucidated.