We searched PubMed between Jan 1, 2009, and July 31, 2019, to identify publications directly relevant to the FAKTION clinical setting using the search terms “AKT” or “PI3K” or “mTOR” and “oestrogen receptor” and “breast cancer” and “metastatic” and “inhibitor” or “inhibition”. The gene discussed is AKT1; the disease is breast cancer.