ITIH4 and Parkinson disease: In an Alzheimer's disease model, amyloid‐β could upregulate astrocytic NOX2 which induced astrogliosis.17 In the lipopolysaccharide (LPS)‐induced PD model, the expression of NADPH oxidase complex is increased and it is significantly involved in the pathogenesis of PD.114 HIV‐1 glycoprotein 120 (gp120) is a well‐known capsid protein of human immunodeficiency virus which is closely related to the AIDS‐induced neurotoxicity.