KLK3 and cancer: 9 However, these studies did not focus on high‐risk patients and did not adjust for metformin effect. Our finding differs from a published study by Yu et al, which found that decreased risk of PCa mortality was more pronounced when patients used statins both before and after cancer diagnosis.34 The discrepancy might stem from differences in study populations and data sources (the study by Yu et al did not include cancer stage, Gleason grade, or PSA in most of the patients).