ADAMTS5 and osteoarthritis: Furthermore, the expression of osteoarthritis marker proteins, such as COL‐X, RUNX2, MMP‐13 and ADAMTS‐5 increased, while a decrease in the hardness of cartilage tissue can be observed.95 Low‐level expression of GLI3 inhibitor in Col2aCre;Ift88fl/fl mutant mice might be associated with the abnormal activation of the Hedgehog pathway.