CASC8 is located in the 8q24 region with few functional annotation genes, meaning that it is possible to carry multiple non‐coding transcripts to perform a variety of functions.23 Hu et al reported that lncRNA CASC8 suppresses the proliferation of bladder cancer cells by down‐regulating glycolysis.24 Moreover, the genetic polymorphism of CASC8 has also been reported as a biomarker for the diagnosis of lung, gastric, and colorectal cancer.14, 25, 26 However, there is no study investigating the relationship between the CASC8 polymorphism and TB susceptibility. The gene discussed is CASC8; the disease is colorectal cancer.