Furthermore, ANGPTL2 was abundantly expressed in infiltrating macrophages within the vessel walls of patients with abdominal aortic aneurysms and in a CaCl2-induced abdominal aortic aneurysm mouse model, while ANGPTL2-deficient mice showed decreased abdominal aortic aneurysm development compared with wild-type mice and lower expression of pro-inflammatory cytokines [11]. The gene discussed is ANGPTL2; the disease is abdominal aortic aneurysm.