Thus, given the importance of ACSL3 in KRAS-driven tumorigenesis, and due to the fact that ACSL3 preferentially utilizes long-chain fatty acids, including arachidonate as substrates [18], we set out to investigate whether ACSL3 plays a role in mediating the KRAS-dependent prostaglandin production in lung cancer. The gene discussed is KRAS; the disease is lung cancer.