LPIAT1 knockdown caused either a mild decrease (H596) or had no effect (H838) in PGE2 production in ACSL3-independent cancer cell lines, while significantly decreased PGE2 production in the ACSL3-dependent cell lines, H125 and HCC95 (Supplementary Figs. 2B and 2C). The gene discussed is MBOAT7; the disease is cancer.