To assess the relationship between ACSL3 and LPIAT1 expression, we employed a NSCLC cohort that includes squamous lung carcinomas (LUSC) and lung adenocarcinomas (LUAD), stratified by ACSL3-high and ACSL3-low expression, and we found a direct correlation between the expression levels of LPIAT1 and ACSL3, suggesting a co-regulation of these enzymes in NSCLC (Fig. 4d). Here, ACSL3 is linked to lung adenocarcinoma.