To adjust for potential confounding factors, a multivariate linear regression model including independent variables TSH, age, gender, body mass index (BMI), THRT, BUN/creatinine ratio >20, urine protein/creatinine ratio >3000 mg/g, Tacrolimus level >12 ng/mL, CRP value >5 mg/dL, arterial hypertension and diabetes mellitus was established. The gene discussed is CRP; the disease is diabetes mellitus.