Similar to protein expression in cell lines (Fig. 1A), GRP78 was highly expressed in tumor tissues collected from NIC/ADR-RES xenograft, IRE1α expression was higher in SKOV3 and TOV-21G xenograft tissues, and PERK expression was highest in TOV-21G xenograft compared to the average expression of each protein in all xenografts. This evidence concerns the gene ERN1 and neoplasm.