NFE2L2 and non-small cell lung carcinoma: For the first time, we revealed the significant correlation of mutations in 4 genes, including EGFR, TP53, NFE2L2 and PIK3CA, with the specific histologic subtype of NSCLC in a single cohort study (Table 2), emphasizing the value of utilizing these molecular markers for subclassifying NSCLC patients and unearthing the distinct potential tumorigenesis mechanisms for NSCLC histologic subtypes.