Given that depletion of monocyte/macrophages using liposome clodronate before IRI resulted in a decrease in the number of kidney macrophages, less severe injury, and inflammation in animal models, the newly appearing CD68+ macrophages in ATN seem to be proinflammatory monocytes/macrophages that participate in injury10. This evidence concerns the gene CD68 and oculocutaneous albinism type 1.