APOE and Cognitive impairment: As opposed to currently available techniques for ApoE4 determination, the e4Risk test presents several advantages that allow its implementation within the clinical routine: First, the analysis can be performed in the same sample that other routine tests, without any preprocessing, which facilities its inclusion in routine laboratory test panels, such as the battery of tests performed in patients being evaluated for cognitive disorders (such as TSH, Vitamin B12, renal and hepatic function tests).