Another example of the gene network architecture of leukemia emerges by tracking up- and downstream interconnections of the genes PIK3CG (DEG-DMG) and PIK3CD (a DMG network hub, Fig. 2) from the PI3K/AKT signaling pathway (enriched in the set of DEG-DMGs, Fig. 6). The gene discussed is AKT1; the disease is leukemia.