CSDE1 and neoplasm: B16 cells expressing CSDE1* generated partial therapy (p = 0.0009 and 0.002 Log-Rank test with Holm–Bonferroni correction for multiple comparisons), whereas the B16-APOBEC3BACTIVE vaccine was significantly more effective, highlighting the value of vaccination with a wide range of antigens to prevent tumor escape (p = 0.0442 and 0.001 Log-Rank test with Holm–Bonferroni correction for multiple comparisons).