Consistent with our murine data, while T-cell activation in the presence of Mel888-GFP cells induced IFNγ secretion, proliferation, and tumor killing, Mel888-APOBEC3BACTIVE coculture significantly enhanced each of these T-cell functions (Fig. 6b) (p = 0.00636, 0.00285, and 0.00479, respectively Student’s t test). This evidence concerns the gene IFNG and neoplasm.