Based on the RNA expression levels of ADAR1 and ADAR2 as detected by quantitative polymerase chain reaction (qPCR), ESCC tumors were divided into four groups: ADAR(1/2)high and ADAR(1 and 2)normal/low or ADAR2high, and ADAR2normal/low (Supplementary Fig. 5a). The gene discussed is ADAR; the disease is esophageal squamous cell carcinoma.