MYC and neoplasm: Similar to previous reports4,32,33, c-Myc and glutaminase (encoded by GLS1) were found to be significantly upregulated in human primary TNBC tumor biopsies compared with healthy breast tissue (Fig. 1b–f; see Supplementary Fig. 1a for remaining blots); the expression of both isoforms of GLS1 (KGA, kidney-type glutaminase and GAC, glutaminase C) was observed in TNBC biopsies (Fig. 1d, Supplementary Fig. 1a).