CFHR1 and age-related macular degeneration: Analogous GWAS meta-analysis of FH levels also revealed a single genome-wide significant association confined to variants in tight LD in a ~150 kb region at the CFH locus (chr1q31.3:196,674,714–196,825,287; including rs6677604, a proxy for the previously reported AMD protective CFHR1–3 deletion29) (Fig. 4b, Supplementary Fig. 6b, Supplementary Data 6, Supplementary Data 7 and Supplementary Data 8), but effect on FH levels was limited (β = −0.10, P value = 2.4 × 10−11, Wald test, at the top variant rs74696321).