While both haplotypes carry the FHR-4-lowering/AMD-protective alleles A of rs10922109 (1.1) and G of rs570618 (1.2), H2 carries the FHR-4-lowering/AMD-protective allele T of rs61818925 (1.6) and H3 carries the FHR-4-lowering/AMD-protective allele A of rs6677604, tag for the AMD-protective CFHR1–3 deletion. Here, CFHR1 is linked to age-related macular degeneration.