CFHR4 and age-related macular degeneration: Remarkably, among the genotypes that contain one copy of H1 (Y402H), diplotypes H1:H2, H1:H3 and H1:H7 showed a significantly lower AMD risk (OR = 0.33, P value = 5.3 × 10−152, OR = 0.29, P value = 1.0 × 10−161 and OR = 0.42, P value = 2.2 × 10−24, respectively, in IAMDGC; Wald test) and decreased levels of FHR-4 (β = −0.54, P value = 2.0 × 10−16, β = −0.31, P value = 8.0 × 10−6 and β = −0.54, P value = 0.001, respectively, in our two-cohort meta-analysis), compared to reference H1:H1 genotype.