Notably, the intronic AMD risk variant rs6685931 in CFHR4 (LD with rs10922109: R2 = 0.43, D′ = 0.96), associated with complement activation in the recent GWAS39, was strongly associated with levels of FHR-4 (β = 0.28, P value = 2.3 × 10−25, Wald test), but not FH (β = 0.005, P value = 0.607, Wald test). The gene discussed is CFHR4; the disease is age-related macular degeneration.