Indeed, in Cds mutant males, where Diacylglycerol (DAG) levels are reduced, there is an overgrowth of both spermatid mitochondrial derivatives and endomembranes, leading to discoordinated ICs like those observed in mulet mutant testes (Laurinyecz et al., 2016), again suggesting that the failure to remove molecular ‘clutter’ in the cyst can result in individualization failure. The gene discussed is CDS1; the disease is cyst.