Consistent with the converged network module of the PPI subnetworks for autism, epilepsy, and learning/memory (Fig. 5h), the shared module of these three gene-pathway bipartite subnetworks also involve NMDARs (Grin1, Grin2a, and Grin2b) as hubs connecting to 16 pathways (Additional file 1: Figure S8 I and Additional file 2: Table S31). Here, GRIN1 is linked to epilepsy.