It has been reported that treatment with nicotinamide rescues both short- and long-term memory impairment in 3xTg-AD mice, the triple-transgenic mice which harbor a knock-in mutation of PSEN1M146V, the Swedish double mutation of APPKM670/671NL, and a frontotemporal dementia mutation in tau (tauP301L) on a 129/C57BL/6 background [23]. Here, MAPT is linked to Alzheimer disease.