Of note is the accumulation of ligands for the C-C chemokine receptor 5 (CCR5) and C-X-C chemokine receptor 3 (CXCR3) receptors such as chemokine (C-C motif) ligand 3 (CCL3), CCL4, CCL5 and C-X-C motif chemokine ligand 9 (CXCL9), CXCL10, CXCL11, respectively, that act as signals for the migration of CD8+ T cells and NK cells and are associated with IFN-γ and anti-tumor effects. Here, CD8A is linked to neoplasm.