NF-κB p65, MMP-2 promoter-driven luciferase reporter, and NF-κB-responsive secreted alkaline phosphatase (SEAP) reporter were ectopically expressed in TSWU-BR4-treated NPC cells and subsequently evaluated NF-κB-dependent SEAP activity, MMP-2 promoter activity, and cellular localization and phosphorylation of NF-κB. Here, NFKB1 is linked to nasopharyngeal carcinoma.