Collectively, we propose a working model whereby by TSWU-BR4 can induce inhibition of cancer cell invasion (Figure 7): TSWU-BR4 induction of the formation of ceramide-rich lipid raft membrane-associated p110-free homodimerized p85α–unphosphorylated PTEN tetrameric complexes by triggering the lipid raft membrane translocation of ASM to catalyze the hydrolysis of sphingomyelin to ceramide. Here, PTEN is linked to cancer.