Collectively, we propose a working model whereby by TSWU-BR4 can induce inhibition of cancer cell invasion (Figure 7): TSWU-BR4 induction of the formation of ceramide-rich lipid raft membrane-associated p110-free homodimerized p85α–unphosphorylated PTEN tetrameric complexes by triggering the lipid raft membrane translocation of ASM to catalyze the hydrolysis of sphingomyelin to ceramide. This evidence concerns the gene SMPD1 and cancer.