Thus, induction of ASM-mediated ceramide generation by TSWU-BR4 disrupted the lipid raft membrane-associated GRP78−p85α−GTP-Rac1-mediated signaling and then impaired NF-κB-mediated MMP-2, triggering the inhibition of NPC cell invasion. The gene discussed is RAC1; the disease is nasopharyngeal carcinoma.