PTEN and cancer: A link to exert enzymatic activity of PTEN as a PIP3 phosphatase has been described by formatting a p85α−PTEN complexes in the plasma membrane [7,52]; however, we observed only a small amount of p85α−unphosphorylated PTEN complexes in the plasma membrane of vehicle-treated cancer cells, which in turn changes and increases localization in the lipid rafts membrane when exposed to TSWU-BR4.