The activation of the phosphoinositide 3-kinase (PI3K)/v-akt murine lymphoma viral oncogene homolog (AKT)/mammalian target of rapamycin (mTOR) pathway is a main driver of cell growth, proliferation, survival, and chemoresistance of cancer cells [1,2,3,4,5]. The gene discussed is PIK3CG; the disease is cancer.