Further examples involve the development of a small panel, composed of seven differentially expressed genes (ANXA3, CLEC4D, LMNB1, PRRG4, TNFAIP6, VNN1 and IL2RB), able to discriminant between subjects according to their relative risk for colorectal cancer in an average-risk population based on 642 samples [27]. The gene discussed is TNFAIP6; the disease is colorectal cancer.