CDK4 and neoplasm: Consistent with the literature, where bone tumors are termed as highly heterogeneous, highly mutable, and genetically unstable, members described in Communities 4 and 9 (TP53, ATM, ATR, CHEK1, BLM, BRCA1, BRCA2, RAD51, MLH1, CDK2, CDK4) explain many of these key features within OS, and can also be associated with important clinical characteristics such as tumor aggressiveness, metastasis, and poor survival.