Although in this study, data from samples of bone tumors were not taken into account, their results showed the members of the PI3K signaling pathway as central onco-drivers, ATR-BRCA1 as regulatory nodes of repair processes associated with TP53, CHEK1 and AKT as the main regulators of cell cycle in function of CDK1A, and CDK1B and activators for downstream pathways such as FOXO. This evidence concerns the gene PIK3CA and bone neoplasm.