Consistent with the literature, where bone tumors are termed as highly heterogeneous, highly mutable, and genetically unstable, members described in Communities 4 and 9 (TP53, ATM, ATR, CHEK1, BLM, BRCA1, BRCA2, RAD51, MLH1, CDK2, CDK4) explain many of these key features within OS, and can also be associated with important clinical characteristics such as tumor aggressiveness, metastasis, and poor survival. Here, CDK4 is linked to bone neoplasm.