Another enzymatic target for Aβ production is γ-secretase, the catalytic component of presenilin-1 (PS-1) and glycogensynthase kinase-3β (GSK-3β), which decreased when human neuroblastoma SHSY5Y cells were treated with CUR, suggesting that CUR decreased Aβ production by inhibiting GSK 3β-dependent PS-1 activation [70]. This evidence concerns the gene PSEN1 and neuroblastoma.