LEP and breast carcinoma: Guo et al. reported a complex crosstalk between leptin, Notch, and Interleukin-1 (IL-1) (NILCO, Notch, IL-1, and leptin crosstalk outcome) that seems to be the integration of developmental, pro-inflammatory, and pro-angiogenic signals critical for leptin-induced cell proliferation/migration and regulation of VEGF/VEGFR-2 in breast cancer [65].