Pevonedistat (MLN4924/TAK-924) is a potent inhibitor of the Nedd8-activating enzyme (similar to the ubiquitin-activating E1 enzyme) that has shown efficacy in killing a variety of cancer-cell types, and has been under clinical investigation for treating leukemia in addition to solid tumors [206,207,208]. This evidence concerns the gene UBA1 and cancer.