NEK2 and malignant colon neoplasm: Four kinases-serine/threonine-protein kinase Nek2 (NEK2), aurora kinase A (AURKA), cyclin-dependent kinase 1 and 2 (CDK1 and CDK2) were the predicted to be activated across breast cancer, colon cancer, LUAD, ovarian cancer, and UCEC (Figure 5a).