Using a CRISPR/Cas9 system, Nechiporuk et al. showed that knockout of TP53, BAX, and PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) genes resulted in BCL-2 inhibitors refractoriness in AML cell lines. The gene discussed is TP53; the disease is acute myeloid leukemia.