These data mining findings suggest that APQ4 may not directly impact the transcription of TGFB1. On another hand, according still to the MEM database and webtool, AQP4 tightly co-expresses with angiotensinogen (AGT) (p-value: 2.95−41, Pearson correlation test), a gene upregulated in MS spinal cords [11] and extensively shown to promote the TGFB1 pathway [26,27,28,29]. The gene discussed is AGT; the disease is myeloid sarcoma.