Thus, one might emphasize that alteration in serum cytokine concentrations under hypoxia might be associated with clinical symptoms of AMS: this is in accordance with previous studies showing that IL-1β, IL-6, and TNF-α were increased in AMS patients, or that an inhibition of anti-inflammatory IL-10 was associated with AMS in a genome wide study [31,37,38]. The gene discussed is IL1B; the disease is ablepharon macrostomia syndrome.