TNF and neoplasm: Hot tumors (anti-tumor TME) tend to have increased expression of IFNγ, IL-1α, IL-1β, IL-2, IL-6, IL-12, IL-17, TNFα, IP-10, MIG, and CAMs [45,46] along with activation of immune cell populations including Tcyt, NK cells, Th, Th17 cells, DCs, and functional APC, to generate an anti-tumor immune response and slow tumor growth [47].