Several studies explored the therapeutic use of antibodies in infections caused by Histoplasma capsulatum, Paracoccidioides brasiliensis, and Sporothrix schenckii. Opsonization of H. capsulatum by an IgM directed to a surface-bound, histone 2b-like protein promoted the anti-fungal activity of macrophages and resulted in a faster maturation and stronger acidification of their phagosomes [82]. Here, CD40LG is linked to infection.