ATXN3 and cerebellar ataxia: A recent meta-analysis of the proton MR spectroscopy studies in spinocerebellar ataxias [43] reported that SCA2 gene carriers showed the more pronounced abnormal neurochemical profiles in the pons and cerebellum compared to SCA1, SCA3, SCA6; and Friedreich’s ataxia with decreased NAA/Cr and Cho/Cr (Figure 1) and increased mI/Cr ratios.