Since in our study’s SWI/SNF complexes turned out to be readers of nucleosome acetylation governed by EP300-HDAC1 balance intwo distinct cell types (human macrophages and two breast cancer cell lines), one might think that BRG1 confers active gene transcription in other cancer types characterized by BRG1 overexpression. The gene discussed is SMARCA4; the disease is breast carcinoma.