Our study also shows the genomic aspect that explains BRG1’s role in breast cancer progression, where the activity of this enzyme maintains a high transcription rate of genes encoding direct drivers of cell proliferation that can act at different cellular levels—signaling cascades (CDK2, CDK4, CCNB—cell cycle phase progression), checkpoints (CHEK2 responses to genome integrity assessment), DNA replication (PCNA—DNA clamp and scaffold for DNA polymerase) and many others listed in Table S2. This evidence concerns the gene SMARCA4 and breast carcinoma.