As for breast cancer, analysis of the genomic data from TCGA database showed <2% mutation frequency in invasive breast carcinomas [19], whereas elevated expression of BRG1 occurred in 35% to nearly 100% of analyzed primary tumors and is responsible for the high proliferation rate; it also served as a predictive marker for patients at high risk of developing metastases [20,21]. The gene discussed is SMARCA4; the disease is breast carcinoma.