POT1 mutations are not confined to the OB-fold domain only, instead it spread through entire length of POT1 [78,97,101,102], and likely causative of many disease including CLL [101,102], familial melanoma [96], CMM [97], CP [100], cardiac angiosarcoma [99], and familial glioma [98]. The gene discussed is POT1; the disease is B-cell chronic lymphocytic leukemia.