TLR8 and tuberculosis: In a Han Chinese cohort, another SNP at position −129 in the promoter region (rs3764879: C > G) has been reported to be in complete linkage disequilibrium with TLR8 A1G and, similarly, the allele with enhanced promoter activity exhibited an enhanced reactivity to RNA in the HEK-cell-model, as well as inactivation of MTB in PBMCs [33], thus linking a stronger activation of the TLR8 pathway with protection against TB.