DCAF6 and cardiac hypertrophy: Further, the Nrip-null mice also exhibited a cardiomyopathic phenotype that likely contributed to the impairments in cardiac contractility, including cardiac hypertrophy, ventricular dilation, aberrant sarcomeric (i.e., widening of Z-disk and narrowing of the I-band) and mitochondrial (i.e., cristae disarrangement) structure.