One clear example of the essential role of WNT5A signaling in melanoma cell dissemination is the observation that simultaneous inhibition of WNT5A expression (with an anti-IL-6 antibody) and downstream WNT5A signaling (with the WNT5A antagonistic peptide Box5) effectively impairs melanoma cell migration and invasion [12]. The gene discussed is WNT5A; the disease is melanoma.