Although there are no reports showing that WNT5A-induced MARCKS phosphorylation could affect F-actin rearrangement in cancer cells, an interesting study by Iioka et al. demonstrated that noncanonical WNT11 signaling via MARCKS regulates cortical actin dynamics and the formation of lamellipodia- and filopodia-like protrusions [30]. Here, WNT11 is linked to cancer.