MARCKS and melanoma: Our observation of a crucial role of WNT5A-induced MARCKS phosphorylation in regulation of melanoma cell migration and invasion was further substantiated by the findings that MARCKS localized at the cell leading edge and lamellipodia and filopodia-like protrusions, indicating that WNT5A, by inducing MARCKS phosphorylation at the cellular edge, could modulate the cytoskeleton to influence melanoma cell invasion.