The basis for this conclusion comes from our findings that MARCKS expression might be associated with melanoma progression and patient survival, WNT5A signaling triggers increased expression and phosphorylation of MARCKS, WNT5A increased the localization of phosphorylated MARCKS at the cell leading edge and in its protrusions and, most importantly, blocking MARCKS phosphorylation with the MANS peptide without affecting its expression abolished WNT5A-mediated melanoma cell invasion. This evidence concerns the gene MARCKS and melanoma.