The hazard ratio for progression or death of patients with CD4 THD burst maintained statistical significance by multivariate analyses (HR 6.749, 95% CI 1.678 to 27.139; p = 0.007), when adjusted for gender, smoking habit, tumor histology, immunotherapy drug, line of treatment, number of organs affected, liver metastases, NLR, serum LDH, serum albumin, GRIm Score, G2 lymphocyte profile, and radiological HPD, as did PD-L1 expression ≥ 5%, with HR of 0.287 (95% CI 0.093 to 0.887). Here, CD4 is linked to neoplasm.