The analysis of the cerebrospinal fluid of the MS patients with either clinically isolated syndromes or relapsing–remitting MS showed increased level of TPPP/p25 as compared to the non-MS patients, indicating the potency of TPPP/p25 to be a biomarker of MS [119], but further efforts are needed to apply it in the clinical practice. Here, TPPP is linked to myeloid sarcoma.