The hallmarks of these diseases are SYN and TPPP/p25; both proteins are disordered with chameleon characteristics and expressed distinctly in neurons and OLGs, respectively [5,16,105,106]; however, they are co-enriched and co-localized in pathological inclusions in the case of PD and MSA [7,107,108,109]. The gene discussed is TPPP; the disease is Parkinson disease.