It is nonetheless noteworthy that some reported cases, in which TUBA1A-mutation associated lissencephaly shows comorbidity with Hirschsprung disease and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) [274], highlight the difficulties in diagnosis associated with a broad spectrum of genetic and phenotypic variations, all of them closely related to the cytoskeletal function in neurons. This evidence concerns the gene TUBA1A and Lissencephaly.