BRAF and melanoma: Additionally, the following reasons led us to the selection of this cell line: i) both superparamagnetic iron and silica nanoparticles proved to be reliable nanoplatforms for the detection and treatment of different cancers, including melanoma [40,52,53,54,55] and ii) A375 melanoma cell line presents the characteristics of the human genitor and possess B-RAF and CDKN2 mutations, which are typical of cutaneous melanoma, representing an eligible candidate for the development of in vivo models [56].