Furthermore, viral penetration of the melanoma cell lines increased by increasing the density of receptors on the surface of the cells: thus, for 23.27% and 16.56% of mel Il and mel Ibr cells expressing CD46 receptor, respectively (Figure 6), an initial amount of virus intracellularly composed 7.2 × 107 and 1.6 × 106, respectively, for this cells at 3 h post infection at a MOI of 1.0 (Figure 5), while 87.67% of mel Mtp cells and 74.50 % of mel Z cells expressing CD46 (Figure 6) corresponded to 9.7 × 108 and 1.9 × 109 viral load at a MOI of 1.0 (Figure 5), respectively. The gene discussed is CD46; the disease is melanoma.