CD46 and melanoma: To confirm the role of CD46 molecule expression on the surface of our melanoma cells in viral oncolysis, the mel Z cells were infected with MV at a MOI of 1.0 again in the presence of anti-CD46 mAbs or isotype control mAbs and viral RNA expression was measured in cell lysates by qPCR-RT after 4 h of incubation (Figure 7).