Thus, the combined low levels or lack of IFN-β and PKR refractory to stimulation, together with the separate expression of ISGs, notably OAS and MxA, could create an environment favorable to MV replication acting as pro-apoptotic and anti-proliferative signals, mediating the death of melanoma cells comparing with normal cells, although the cell death mechanism depended on the cell line tested. This evidence concerns the gene IFNB1 and melanoma.