Thus, such selectivity is possible based on the receptor tropism of oncolytic viruses, as in case of MV overexpression of the CD46 molecules in tumor cells [13], or tumor-related abnormalities in the regulation of mRNA translation suppressing IFN-induced inhibition of cell proliferation and apoptotic signaling, however, also facilitating selective replication of viruses in tumor cells [21]. The gene discussed is IFNA1; the disease is neoplasm.