Localized scleroderma is a complex disease featuring inflammation and fibrosis caused by higher than normal collagen deposition; entailing a decrease in functional T regulatory cells, the inflammation in scleroderma shows a specific profile of increased chemokine (C-X-C motif) ligands 9 and 10 (CXCL9 and CXCL10) expression with a decrease in IL-23 and IL-17A T-helper 17-related cytokines [137,138]. The gene discussed is CXCL10; the disease is scleroderma.