Among these components, TGF-β can cause immunosuppression and promote tumor growth and survival, TNF-α is involved in cellular transformation, survival, and proliferation, while MMPs can favor tumor invasion through epithelial–mesenchymal transition in many cancers; all these molecules are found in the intersecting pathways of inflammation and carcinogenesis, and cannabinoids can regulate their expression [140,160,161,162,163,164,165,166]. The gene discussed is TNF; the disease is neoplasm.