CXCL1 and neoplasm: CBD also induces apoptosis in Kaposi sarcoma-associated herpesvirus-infected endothelial cells in vitro by inhibiting viral G protein-coupled receptor (vGPCR) and reducing growth-regulated protein α (GRO-α), VEGF-C and VEGF-receptor 3 levels, thus hindering the tumor cells growth and transformation; GRO-α, a chemokine acting as an agonist for vGPCR, is a key regulator of inflammation, angiogenesis, and tumorigenesis, hinting at an interconnection of these processes in the tumoral environment [195].