MECP2 and atypical Rett syndrome: In an experimental model of Rett syndrome (the Mecp2 gene-mutated neurodevelopmental female disease that shares several symptoms with ASD [67]), obtained by MECP2-knockdown in human primary neural cell cultures, it has been demonstrated that exosomes extracted from hiPSC-derived neural cultures were able to rescue the decrease in neuronal growth and differentiation, whereas those extracted from MECP2-deficient neuronal h-iPS cells could not [68].